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SurgihoneyRO

Antimicrobial wound gel

SurgihoneyRO™ is a cutting-edge technology, an antimicrobial wound gel utilising bio-engineered honey to deliver Reactive Oxygen®.

Effective against multi-drug resistant microorganisms commonly found in chronic wounds1.

For more detailed information, please visit www.surgihoneyro.com

FEATURES

Product Benefits

SurgihoneyRO™ provides enhanced healing and a powerful antimicrobial action to reduce the microbial load thus removing the barriers to wound healing. Unlike other medical grade honeys, SurgihoneyRO™ has been bioengineered to enhance and precisely control its antimicrobial potency.

Benefits of SurgihoneyRO™

  • Kills a wide range of bacteria in vitro2,3,4
  • Prevents biofilm in vitro2
  • Fast acting antimicrobial action3
  • Substantially eradicates mater biofilm in vitro5,6

Benefits of SurgihoneyRO™ natural honey base

  • Effective debridement7
  • Assists the natural wound healing enviroment
  • Reduces pain and inflammation
  • Protects the wound bed helping to prevent pain and trauma at dressing change
  • Neutralises malodour
  • Promotes new tissue growth
How does RO™ in SurgihoneyRO™ work?

SHOW REFERENCES

  1. Perfectus Biomed, data on file 2018
  2. F. Halstead F, Webber M, Rauf M, Burt R, Dryden M, Oppenheim B. In vitro activity of an engineered honey, standard medical-grade honeys and antimicrobial wound dressings against biofilm producing clinical bacterial isolates. Journal of Wound Care, Feb 2016.
  3. Dryden M. Lockyer G. Kordo S. Cooke J. Engineered honey: in vitro antimicrobial activity of a novel topical wound care treatment. Journal of Global Antimicrobial Resistance 2014. 10.1016/j.jgar.2014.03.006
  4. Dryden M, Milward G, Saeed K. Infection prevention in wounds with Surgihoney. Journal of Hospital Infection 2014. Oct;88(2): 121-2.doi:10.1016/j.jhin.2914.07.008.Epub 2014 Aug1.
  5. Perfectus Biomed report May 2017, data on file.
  6. Halstead F, Use of an engineered honey to eradicate pre-formed biofilms of important wound pathogens: an in vitro study, Journal of Wound Care, 2017.
  7. Dryden M, Dickinson A, Brooks J, Hudgell L, Saeed K, Cutting K. A multi-centre clinical evaluation of Reactive Oxygen® topical wound gel in 114 wounds. Journal of Wound Care, March 2016.
  8. Halstead F, Webber M, Rauf M, Burt R, Dryden M, Oppenheim B. In vitro activity of an engineered honey, standard medical-grade honeys and antimicrobial wound dressings against biofilm-producing clinical bacterial isolates. Journal of Wound Care, Feb 2016.
  9. Halstead F, Use of an engineered honey to eradicate pre-formed biofilms of important wound pathogens: an in vitro study, Journal of Wound Care, 2017. 9.

Cost Effective

SurgihoneyRO™ is a single patient multi-use product which provides a clinically and cost-effective treatment regime and once opened may be used for up to 28 days.

SurgihoneyRO™  may be use for infected wounds through to healing.

1. Perfectus Biomed, data on file 2018


Performance

When SurgihoneyRO™ comes into contact with moisture, Reactive Oxygen® is instantly released and sustained for over 72 hours10.

SurgihoneyRO™ has all the natural healing-inducing, desloughing and tissue regenerative properties of the honey carrier, but it has been bioengineered to delivery precisely controlled level of Reactive Oxygen®.

SurgihoneyRO™ is a fast acting, effective antimicrobial.

SurgihoneyRO™ not only inhibits but also kills microbes at concentrations 10-1000 fold below those that are likely to be achieved in topical treatment. The speed of cidal activity is shown by the time-kill curves to be extremely rapid11.

SHOW REFERENCES

10. Kwakman PH, te Velde AA, de Boer L et al (2011) Two major medicinal honeys have different mechanisms of bactericidal activity. PLoS One 6(3): e17709.

11. Wounds UK (2013) Best Practice Statement. The use of tropical antimicrobial agents in wound management (third edition). London: Wounds UK.


Clinical Evidence

SurgihoneyRO™ is supported by in vitro and clinical studies and has recently been recommended for use by Public Health England. Public Health England’s guidance on common infections recognises SurgihoneyRO™ as a treatment for venous leg ulcers to reduce bacterial load and infection2 explaining it could cut unnecessary antibiotic prescribing.

Below is a case study of a 91 year old lady, who used SurgihoneyRO™ for 14 days to treat a long term leg ulcer.

Key clinicals

Author
Title
Publication
Link

Stephens, C.

Clinical Evaluation of 54 Patients in the UK of a Bioengineered Reactive Oxygen® Wound Gel in the Treatment and Management of Wound Infection.

Wounds UK, 2019, poster

Filipini, R.

H₂0₂ (SurgihoneyRO™) – Fast effective autolytic debridement and healing in long standing infected chronic wounds

TVS, 2019, Poster

Dryden, M. and Stephens, C.

Reactive Oxygen® Made Easy

Wounds UK, 2018, 14(5)

Clarke, L.

The evaluation of SurgihoneyRO™ in the treatment of chronic wounds with suspected biofilms

Wounds UK, 2018, 14(5)

Dryden, M., Dickinson, A., Hudgell, L., Brooks, J., Saeed, K. and Cutting, K.F.

A multi-centre clinical evaluation of SurgihoneyRO™ in 114 wounds

Journal of Wound Care, 2016, 25(3)

Public Health England

Management and treatment of common infections

Antibiotic guidance for primary care: For consultation and local adaptation

(See Page 66 for SurgihoneyRO™ recommendation)

Public Health England, October, 2018

Dryden, M., Goddars, C., Madadi, A. et al

Using antimicrobial SurgihoneyRO™ to prevent caesarean wound infection

British Journal of Midwifery, 2014, 22(1)

Dryden, M., Tawse, C., Adams, J., et al.

The use of SurgihoneyRO™ to prevent or eradicate bacterial colonisation in dressing oncology long vascular lines

Journal of Wound Care, 2014

In Vitro studies

Author(s)

Title

Publication

Thomas, H., Davies, L. and Westgate, S.J.

Treatment of World Health Organisation priority pathogens using an antimicrobial wound gel

Wounds UK, 2018

Thomas, H., Davies, L. and Westgate, S.J.

A topical antimicrobial wound gel to treat multi-drug resistant pathogens in wound care

Wounds UK, 2018

Davies, L., Thomas, H. and Westgate, S.

Multi-Species Biofilm Disruption by Two Wound Care Products Using a Colony Drip Flow Model

TVS conference, 2018

Halstead, F.

Use of an engineered honey to eradicate pre-formed biofilms of important wound pathogens: an in vitro study

Journal of Wound Care, 2017, 26(7)

Halstead, F.

In vitro activity of an engineered honey, medical-grade honeys, and antimicrobial wound dressings against biofilm-producing clinical bacterial isolates

Journal of Wound Care, 2016, 25(2)

Cooke, J.

The antimicrobial activity of prototype modified honeys that generate reactive oxygen species (ROS) hydrogen peroxide

BMC Research Notes, 2015, 8(20)

Dryden, M.

Bioengineered honey: in vitro antimicrobial activity of a novel topical wound care treatment

Journal of Global Antimicrobial Resistance & Journal of Antimicrobial Chemotherapy, 2014

1. Perfectus Biomed, data on file 2018
2. Public Health England: Management and treatment of common infections: Antibiotic guidance for primary care: for consultation and local adaptation.

SHOW REFERENCES

  1. F. Halstead F, Webber M, Rauf M, Burt R, Dryden M, Oppenheim B. In vitro activity of an engineered honey, standard medical-grade honeys and antimicrobial wound dressings against biofilm producing clinical bacterial isolates. Journal of Wound Care, Feb 2016.

Indications

SurgihoneyRO™ is indicated for infected wounds, chronic and acute wounds through to wound healing.

Chronic wounds including:

  • Diabetic foot ulcers
  • Pressure ulcers
  • Leg ulcers
  • Infected wounds

Acute wounds including:

  • Surgical wounds
  • Traumatic wounds, cuts & abrasions
  • Burns
  • Donor & recipient sites

Applying SurgihoneyRO™*

Applying SurgihoneyRO™

  • Cleanse the wound as per local guidelines
  • Apply 2mm thickness directly to the wound bed. Alternatively, SurgihoneyRO™ can be applied to an inert wound contact or secondary dressing then placed on the wound bed
  • Select an appropriate secondary dressing for exudate level and to maintain moist wound healing environment
  • A tube of SurgihoneyRO™ may be used on a single patient, multiple times, for up to 28 days

Removing SurgihoneyRO™

Residual wound gel can be removed during the normal wound cleansing regime.

Frequency of application following surgery

It is recommended to apply SurgihoneyRO™ once immediately after closure to assist healing and as an infection prevention measure. For surgical wounds at high risk of infection, e.g. abdominal surgical sites, continue to apply SurgihoneyRO™ at each dressing change.

Wear time of SurgihoneyRO™

It is recommended that SurgihoneyRO™ is applied every 72 hours (three days) and more frequently in critical wound infections to maximise effect. SurgihoneyRO™ may be used under compression bandaging for up to 7 days however potency will decrease after day 3.

*See product insert leaflet for full instructions for use


Education

Surgihoney RO e-learning

FAQs

Click on the image below to view the FAQs


Ordering Details

Size Product code PIP code NHS code
SurgihoneyRO™* 20g tube RO151247 407-1205 Coming soon
SurgihoneyRO™* 50g tube RO151248 407-1213 Coming soon

*SurgihoneyRO™ is single patient, multi-use and once opened can be used for up to 28 days.

Perfectus Biomed, data on file 2018


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