Ultrasound Healing Therapy


MIST® Therapy is a non-contact low frequency ultrasound delivered through a saline mist.

The sound waves of this non-thermal, painless treatment penetrate into and below the wound bed to mechanically stimulate cells.

MIST® Therapy addresses the barriers to healing by stimulating the wound environment and actively impacting the wound bed.

The gentle sound waves of MIST® Therapy penetrate into and below the wound bed and as a result, healing barriers are removed and cells are stimulated to accelerate the normal healing process.

Removing barriers

  • Reducing sustained inflammation[12,19]
  • Reducing MMP-9[19]
  • Reducing a wide range of bacteria[4,11,14]
  • Disrupting biofilm[20]

Stimulating cells

  • Increased perfusion through vasodilation[16]
  • Earlier release of growth factors[17,19]
  • Increasing angiogenesis[18]
  • Increasing collagen deposition[18]


Clinical results show twice the healing in half the time when using MIST® therapy vs. standard of care, providing substantial cost savings to the NHS for costly chronic wounds by reducing the length of time that chronic wounds require attention and so decreasing costs associated with nursing time, wound dressings, hospital admissions and surgical interventions (including occasionally, amputation).

Non-healing chronic wounds including nursing time may cost £39,000 as cited in health economic studies[21].
The case study presented below shows accelerated healing in a 5 year non-healing ulcer after treatment with MIST® Therapy. The total treatment costs were £1,150 for 18 treatments over 77 days providing the opportunity for substantial savings[21].


MIST® Therapy is supported by a vast array of clinical evidence and has recently been reviewed by NICE resulting in a research RCT following NICE guidance: “MIST® Therapy system for the promotion of wound healing in chronic and acute wounds”.

MIST® Therapy Meta-analysis

Eight peer-reviewed studies found to be consistent in both the treatment and control groups were pooled to review the effects of MIST® Therapy on wound size, volume, pain and healing time.

Summary of findings:

  • 85.2% area reduction in 7 weeks
  • 79.7% volume reduction in 12 weeks
  • 42% healed at 12 weeks (compared to 24% for standard care)
  • Mean time to heal = 8.2 weeks
  • 79% pain reduction*

MIST® Therapy demonstrates remarkable consistency of reduction in wound area, volume, pain and healing times across a wide range of wounds

* MIST® Therapy is not FDA approved for the reduction of pain. Further clinical research is required.

MIST® clinical studies

Author(s) Title Publication
1 Driver, V., R. Yao M. and Miller, C.J. Noncontact low-frequency ultrasound therapy in the treatment of chronic wounds: A meta analysis Wound Repair & Regeneration, 2011, 19(4) View
2 Ennis, W.J., et al. Ultrasound Therapy for recalcitrant diabetic foot ulcers: results of a randomised, double-blind controlled, multicentre study Ostomy Wound Management, 2005, 51(8) View
3 Kavros, S.J., Miller, J.L. and Hanna, S.W. Treatment of ischaemic wounds with noncontact, low-frequency ultrasound: the Mayo Clinic experience 2004-2006 Adv Skin Wound Care, 2007, 20(4) View
4 Serena, T., et al. The impact of noncontact, nonthermal, low-frequency ultrasound on bacterial counts in experimental and chronic wounds Ostomy Wound Management, 2009, 55(1) View
5 Gehling, M.L. and Samies, J.H. Unanticipated palliative benefit of noncontact, low-intensity, low-frequency therapeutic ultrasound on lower extremity chronic wound pain Ostomy Wound Management, 2007, 53(3) View
6 Kavros, S.J., et al. Expedited wound healing with noncontact low-frequency ultrasound therapy in chronic wounds: A retrospective analysis Adv Skin Wound Care, 2008, 21(9) View
7 Bell, A.L. and Cavorsi, J. Noncontact ultrasound therapy for adjunctive treatment of non-healing wounds: Retrospective analysis Physical Therapy, 2008, 88(12) View
8 Cole, P.S., Melin, M.M. and Quisberg, J. Adjuvant use of acoustic pressure wound therapy for the treatment of chronic wounds Journal of Wound, Ostomy & Continence Nursing, 2009, 36(2) View
9 Hann, L.S. and Lucich, S. A retrospective analysis of acoustic pressure wound therapy: effects on the healing progression of chronic wounds Journal of the American College of Certified Wound Specialists, 2009, 1(1) View
10 Ennis, W.J. et al. Evaluation of clinical effectiveness of MIST ultrasound therapy for the healing of chronic wounds Adv Skin Wound Care, 2006, 19(8) View
11 Kavros, S.J., Schenck, E.C. Use of noncontact low-frequency ultrasound in the treatment of chronic foot and leg ulcerations: A 51 patient analysis

Journal of the American Podiatric Medical Association, 2007, 97(2)

12 Escandon, J., et al. A prospective pilot study of ultrasound therapy effectiveness in refractory venous leg ulcers International Wound Journal, 2012, 9(5) View
13 Garcia-Lavin, S., et al. Clinical and biological effects of noncontact low-frequency ultrasound on diabetic foot ulcers SAWC, 2011, poster View
14 Kavros, S.J., et al. The effect of ultrasound MIST transfer technology on virulent bacterial wound pathogens Abstract. Presented at Symposium on Advanced Wound Care, 2002
15 Data on file at Celleration.
16 Leidl, D.A. and Kavros, S.J. The effect of MIST ultrasound transport technology on cutaneous microcirculatory blood flow Abstract. Presented at Symposium on Advanced Wound Care, 2001
17 Lai., J. and Pittelkow, M.R. Physiological effect of ultrasound MIST on fibroblasts International Journal of Dermatology, 2007, 46(6) View
18 Thawer, H.A. and Houghton, P.E. Effects of ultrasound delivered through a mist of saline to wounds in mice with diabetes mellitus Journal of Wound Care, 2004, 13(5) View
19 Driver, V.R. and Yao, M. A pilot study evaluating noncontact low frequency ultrasound and underlying molecular mechanism on diabetic foot ulcers International Wound Journal, 2012, Nov-19 on-line publication View
20 Seth, A.K., et al. Noncontact, low-frequency ultrasound as an effective therapy against pseudomonas aeruginosa – infected biofilm wounds Wound Regeneration & Repair, 2013, 21(2)
21 Norris, R., Driver, V.R, et al. Meeting Report: MIST ultrasound therapy: the science and the benefits Wounds UK, 2011, 7(1) View
22 Honaker, J.S., et al. Effects of noncontact low-frequency ultrasound on healing of suspected deep tissue injury: A retrospective analysis International Wound Journal, 2013, 10(1) View
23 Jordan, J. A case study using MIST Therapy to heal chronic non-healing wounds Wounds UK, 2012, poster
24 Edwards, V. and Edwards, J. The use of MIST Therapy on an elderly burn patient Wounds UK, 2011, poster View
25 Furlong, W., Abbot, J. and George, J. The use of MIST Therapy on chronic wounds Wounds UK, 2011, poster View
26 Murray, S. The effects of MIST Therapy on the debridement of an ulcer to a lower limb extremity Wounds UK, 2011, poster View
27 Chadwick, P. The use of MIST Therapy in the management of complex diabetic foot wounds Wounds UK, 2010, poster View
28 Lara, L. MIST Therapy helped to save a foot from amputation Wounds UK, 2010, poster View
29 Stanway, S., Coop, R. et al. The management of chronic wounds using MIST Wounds UK, 2010, poster View
30 Norris, R. and Henchy, R. Use of low frequency ultrasound therapy in the treatment of recalcitrant leg ulcers: case series Wounds UK, 2010, 6(2) View

For all MIST® Therapy device purchase and rental, consumable orders, deliveries and general enquires regarding the MIST® ultrasound healing therapy devices please contact H&R Healthcare:

Tel: +44 (0)1482 631606

Fax: +44 (0)1482 631630

Email: info@hrhealthcare.co.uk

Monday to Friday: 8.30am to 5pm